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Fluorescence patterns of nuclear autoantigens

Autoantibodies recognizing nuclear membrane related antigens



nuclear-membrane image


Nuclear membrane is a lipid bi-layer, and its inner membrane is connected with nuclear lamina. Ribosomes and endoplasmic reticulum are bound to the outer membrane. The nuclear membrane is perforated by multiple nuclear pores through which transportation of molecules between the nucleus and the cytoplasm occurs.


Anti-lamin antibody


photo 42


Pattern Linear fine staining of the nuclear membrane and homogeneous nuclear staining associated with nuclear rim staining are observed. The staining is similar to peripheral pattern. However, the chromosomal region show no staining in mitotic cells.
Antigen Nuclear lamins (intermediate filaments lining the inner nuclear membrane; lamin B (68kD), lamin A (74kD), and lamin C (60kD))
Lamina associated proteins (LAP 1A and LAP 2) also give continuous rim staining of the nuclear envelope.
Clinical significance These antibodies occur in patients with PBC, AIH, chronic fatigue syndrome and viral hepatitis type D.
References 46, 47, 48, 49, 50

Anti-nuclear pore complex antibody


photo 43

Pattern Nuclear membrane (pores) staining, coarse nuclear staining associated with nuclear rim staining in interphase cells.
Antigen gp210 (210kD glycoprotein organizing nuclear pores). The antigenic epitope of this protein is located in its cytoplasmic tail, and also epitopes in its carbohydrate moiety or amino terminal domain directed to the lumen of the pore were reported.
Clinical significance PBC
References 46, 51, 52

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SLE: systemic lupus erythematosus, SSc: systemic sclerosis, MCTD: mixed connective tissue disease, SS: Sjögren's syndrome, PM/DM: polymyositis/dermatomyositis, RA: rheumatoid arthritis, PBC: primary biliary cirrhosis, AIH: autoimmune hepatitis


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