Atlas of Antinuclear Antibodies
The autoantibody testing by indirect immunofluorescence (IIF) has fulfilled the very important roles for the diagnosis and treatment of the patients with autoimmune disorders since its first report by Friou in 1957.
The technique has many advantages for detecting and screening both nuclear and cytoplasmic antibodies in general and categorizing them by their staining patterns. Since the recognized antigens of the ANA (antinuclear antibodies) comprise many nuclear components or proteins and sometimes it is difficult to distinguish them by their staining patterns, these studies have contributed much to the elucidation and understanding of the autoantibodies in connective tissue diseases.
* Photos of cell staining in this photo book were taken by using FLUORO HEPANA TEST (code No. 4210, 4220). Specific staining parts were detected as fluorescent staining (green) and non specific staining parts would be appeared as red because of Evans Blue pigment. Depends on cases, when both parts were over lapped, it would look yellow.
Structure and function of eukaryotic cell and outlines of cell cycle
Fluorescence patterns of autoantibodies
Fluorescence patterns of nuclear autoantigens
- Autoantibodies recognizing chromatin related antigens
- Autoantibodies recognizing non-chromatin related proteins
- Autoantibodies recognizing nucleolus related proteins
- Autoantibodies recognizing cell cycle related antigens
- Autoantibodies recognizing nuclear membrane related antigens
Fluorescence patterns of cytoplasmic autoantigens
- Autoantibodies recognizing antigens of cytoplasmic organelles
- Autoantibodies recognizing mitotic spindle apparatus related antigens
- Autoantibodies recognizing cytoskeleton related antigens