Company Profile

Top Page > Company Profile > Our Business > IVDs: Genetic tests

IVDs: Genetic tests

Genetic tests

Companion diagnostics (CDx):KRAS gene mutation detection kit

"Companion Diagnostics (CDx)" are in vitro diagnostics that provide essential information for the safe and effective use of therapeutic products on the basis of each patient's characteristics such as genetic mutations. The market of ''Personalized Medicine'' including CDx is exploding in worldwide.

In particular, mutations in KRAS gene lead to acquire resistance to anti-EGFR therapeutic antibodies, such as cetuximab and panitumumab, for treatment of colorectal cancer. Hence, the KRAS gene mutations has to be detected before the medication.

"MEBGEN™ KRAS Gene Mutation Detection Kit" rapidly and objectively detects 12 single-nucleotide mutations due to amino acid substitutions at codon 12 and 13 of the KRAS gene, using the PCR-rSSO method (Luminex® method).

[Technical cooperation : G & G Science Co., Ltd.] Wild type and mutated KRAS

HLA DNA typing reagent –GENOSEARCH™ HLA Series Ver. 2–

LHC, Human Leukocyte Antigen HLA (Human Leukocyte Antigen) matching is significantly related to outcomes of transplant therapies including organ and bone marrow transplantations.

"GENOSEARCH™ HLA Series" (HLA-A, -B, -C, -DRB1) Ver. 2 enables 4-digit genotyping of HLA in a short period of time. This reagent was selected for use in donor registration in the Japan Marrow Donor Program in 2007.

[Technical cooperation : G & G Science Co., Ltd.]

HPA DNA typing reagent –GENOSEARCH™ HPA Ver. 2–

In platelet transfusion, transfusion between individuals with non-matching types of human platelet antigen (HPA) can lead to production of anti-HPA antibodies, resulting in subsequent platelet transfusion refractoriness (PTR). In addition, determination of an HPA antigen type plays an important role in predicting neonatal alloimmune thrombocytopenia (NAITP) caused by HPA type-incompatibility between a mother and child.

"GENOSEARCH™ HPA Ver. 2," a HPA test research reagent developed by MBL, can discriminate single-nucleotide polymorphisms (SNPs) that specify eight antigens, HPA-1, HPA-2, HPA-3, HPA-4, HPA-5, HPA-6, HPA-15 and HPA-21 which are regarded as important in clinical settings, as well as a SNP of the CD36 gene (C478T) involved in production of NaK(a) antigen. In addition, because this kit can measure under the same conditions as those in "GENOSEARCH™ HLA Series," HLA types (HLA-A, -B, and -C) and HPA antigen types on the surface of platelet can be simultaneously determined in a single thermal cycling instrument and Luminex® device.

[Technical cooperation : G & G Science Co., Ltd.] HPA, Human platelet antigen

Full Site